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Subcellular Omics Overview

All cells contain spatially distinct niches (e.g. organelles, condensates) that house the different proteins driving metabolism. Our lab develops and applies subcellular omics methods in marine microorganisms to map the subcellular distributions of proteins, elements, and other macromolecules. We use these methods to create subcellular atlases that uncover how metabolism is organized within microbial cells.  

 

We are grateful to the Waller Lab and Kathryn Lilley's group at the University of Cambridge (UK) for sharing their subcellular proteomics knowledge. ​​

A draft t-SNE projection mapping the subcellular spatial proteome of Thalassiosira pseudonana. Green = chloroplast proteins, black = ribosomal proteins, red = mitochondrial proteins, blue = nuclear proteins, orange = Golgi/ER proteins. Can you find your favorite protein? More to come soon. *not optimized for phones*

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